At trezor.io/start, begin setting up your Trezor wallet by connecting your device to a computer or smartphone. Follow the on-screen instructions to initialize your wallet securely. You'll create a strong PIN and write down your recovery seed to safeguard your funds. After setting up, install the Trezor Bridge software for seamless communication between your device and the wallet interface. Use the Trezor Wallet interface to manage your cryptocurrencies, send and receive transactions, and explore additional features like coin management and integration with third-party services. Ensure your device stays up to date with firmware updates for enhanced security and functionality.